Tacrolimus and cyclosporine are the most used options in clinical practice for maintenance therapy. In this study, we performed a cost-effectiveness analysis of tacrolimus versus cyclosporine, evaluating the cost-effective therapeutic scheme in the Colombian context, considering organ rejection avoided as a clinical outcome. The result of this research shows the economic and clinical benefits of the use of both therapeutic schemes, tacrolimus only achieves cost-effectiveness in 1 treatment regimen, being above the cost-effectiveness threshold in the remaining regimen.

Although recommender systems have been used in a wide variety of products, they have not had the same adoption in the insurance sector due to the particular aspects of the industry. The present research proposes a novel model that uses natural language processing techniques and a deep learning-based model to recommend occupational hygiene services. The results of ranking methods showed that the model combining memorization and generalization of companies’ activities preferences performed better compared to other models. These findings have significant implications for decision-making as they can improve the welfare of both companies and workers, while also limiting the options offered to clients based on their unique profiles.

The result of this research shows the economic and clinical benefits of the use of different pharmacological treatments for adult kidney transplant recipients in Colombia, considering the years of life gained and organ rejection avoided. Tacrolimus and cyclosporine are the most used options in clinical practice for maintenance therapy and are included in the cost-effective schemes.
Across the different sets of evidence, tacrolimus+mycophenolate mofetil+corticosteroids, cyclosporine + mycophenolate mofetil+corticosteroids, and cyclosporine+ azathioprine+corticosteroids proved to be the cost-effective strategies in most comparisons.

Some reports suggest there are differences in health needs between the population affiliated to the subsidized health insurance scheme (SS) and those affiliated to the contributory health insurance scheme (CS) in Colombia. The objective of this study was to identify the epidemiological profile of the population affiliated to the SS in Colombia and to compare the main epidemiological features of the SS to the CS.